The Italian Southern Partnership for Advanced Computational Infrastructures (SPACI) is a partnership among the Universities of Lecce and Calabria as well as the Italian Research Council, based on three geographically spread High Performance Computing (HPC) centres located in Southern Italy. Those centres are the University of Lecce's ISUFI/ CACT (Center for Advanced Computational Technologies), the Center for Research on Parallel Computing and Supercomputers (CPS) of the National Research Council (CNR), now section of the CNR Institute of HPCN (ICAR/CNR), and the MIUR/HPC Center of Excellence of University of Calabria. SPACI, funded by the Italian Ministry of Education, University and Research, has been established to pursue excellence in the field of Computational Science and Engineering.

The purpose of the SPACI Consortium is to create a broad collaboration between public and private research compliant with guidelines for scientific and technological policy issued by the Italian government. The SPACI Consortium consists of three entities today: the University of Lecce, HP Italy, and a company created by the three partnership institutions with the name Spaci SrL.